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KMID : 0388220140210060326
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Journal of the Korean Rheumatism Association
2014 Volume.21 No. 6 p.326 ~ p.330
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Leflunomide-induced Toxic Epidermal Necrolysis in a Patient with Rheumatoid Arthritis
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Je Ji-Hye
Lee Hyun-Jung
Na Young-Ju
Seo Ji-Hye
Seo Young-Ho
Kim Jae-Hoon
Choi Sung-Jae
Lee Young-Ho
Ji Jong-Dae
Song Gwan-Gyu
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Abstract
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Leflunomide was licensed for the treatment of rheumatoid ar-thritis in 1998 and has been available in Korea since 2003. Allergic cutaneous reactions (rash, purpura) are common (＜10%) side effects of leflunomide, but severe cases such as Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) are rarely reported. There has not been a report of SJS or TEN induced by leflunomide in Korea. Here we report a case of leflunomide-induced TEN in a patient with rheuma-toid arthritis. Leflunomide was discontinued, and the TEN was treated with methylprednisolone, cholestyramine and immunoglobulin. The skin lesion eventually resolved over four weeks with residual post-inflammatory hyperpigmentation.
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KEYWORD
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Leflunomide, Toxic epidermal necrolysis, Rheumatoid arthritis
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